Call for papers for the forthcoming issue of Hygeia.J.D.Med.10 (1) July 2018.

Abstract

AN HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF RISPERIDONE AND TRIHEXYPHENIDYL HYDROCHLORIDE FROM BULK AND DOSAGE FORMS.
Hygeia J. D. MedVol.3 (1) April 2011- September 2011,29-33 .

Type of Article: Research article

Authors
S.Dharmaraj Santhosam1*, S.Kannan2 
 

Affiliations: 
1.Department of Pharmaceutical Analysis, Smt.Sarojini Ramulamma College of Pharmacy,Sheshadrinagar,Mahabubnagar,                      Andrapradesh, India – 509 001.

  2.Department of Pharmacognosy, Smt.Sarojini Ramulamma College Of Pharmacy,Sheshadrinagar,  Mahabubnagar,Andrapradesh,India  

  Article history: Received: 31 October, 2010,revised: 27 November, 2010, accepted: 11 January, 2011, Available online: 14 April 2011

Abstract

   A simple, fast and precise reverse phasehigh performance liquid chromatographic method developed for the simultaneousdetermination of risperidone and trihexyphenidyl hcl in its tablets form. C18 phenomenex Gemini column 250mm x 4.6mm (l x d)in isocratic mode with mobile phase buffer: Acetonitrile: methanol (50:30:20) %v/v were used. The flow rate was 1 ml/min. Linearity for risperidone andtrihexyphenidyl hcl were in the range of 96.96 mcg/ml – 145.44mcg/ml and 65.60mcg/ml – 98.4 mcg/ml respectively. Amount found of risperidone andtrihexyphenidyl hcl in sizodon plus was 3.034 mg/tab and 2.063 mg/tab respectively.Amount found of risperidone and trihexyphenidyl hcl in RI- plus was 3.016mg/tab and 2.044 mg/tab respectively. Percentage recoveries obtained forrisperidone and trihexyphenidyl hcl in sizodon plus were 100.87% and 102.49%respectively, percentage recoveries obtained for risperidone andtrihexyphenidyl hcl in RI-plus were 100% and 101.65% respectively.  The proposed method is accurate, precise,selective and rapid for the simultaneous estimation of risperidone andtrihexyphenidyl hydrochloride in tablet dosage.

Key words:  HPLC, Validation, Risperidone,Trihexyphenidyl hydrochloride


Article outline

1.Introduction

2.HPLC method development

3.assay,linearity study,accuracy,system suitability

4.Results and discussion



Typical HPLC Chromatogram of Risperidone &  Trihexyphenidyl Hcl


For Correspondence: sdraj1979@gmail.com 

Contact09951424683

© 2011  Hygeia journal for drugs andmedicinesall rights reserved.  2229 3590, 0975 622

Hygeia J. D. Med.





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