Hygeia.J.D.Med.9(1) July 2017 - December 2017

Abstract

AN HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF RISPERIDONE AND TRIHEXYPHENIDYL HYDROCHLORIDE FROM BULK AND DOSAGE FORMS.
Hygeia J. D. MedVol.3 (1) April 2011- September 2011,29-33 .

Type of Article: Research article

Authors
S.Dharmaraj Santhosam1*, S.Kannan2 
 

Affiliations: 
1.Department of Pharmaceutical Analysis, Smt.Sarojini Ramulamma College of Pharmacy,Sheshadrinagar,Mahabubnagar,                      Andrapradesh, India – 509 001.

  2.Department of Pharmacognosy, Smt.Sarojini Ramulamma College Of Pharmacy,Sheshadrinagar,  Mahabubnagar,Andrapradesh,India  

  Article history: Received: 31 October, 2010,revised: 27 November, 2010, accepted: 11 January, 2011, Available online: 14 April 2011

Abstract

   A simple, fast and precise reverse phasehigh performance liquid chromatographic method developed for the simultaneousdetermination of risperidone and trihexyphenidyl hcl in its tablets form. C18 phenomenex Gemini column 250mm x 4.6mm (l x d)in isocratic mode with mobile phase buffer: Acetonitrile: methanol (50:30:20) %v/v were used. The flow rate was 1 ml/min. Linearity for risperidone andtrihexyphenidyl hcl were in the range of 96.96 mcg/ml – 145.44mcg/ml and 65.60mcg/ml – 98.4 mcg/ml respectively. Amount found of risperidone andtrihexyphenidyl hcl in sizodon plus was 3.034 mg/tab and 2.063 mg/tab respectively.Amount found of risperidone and trihexyphenidyl hcl in RI- plus was 3.016mg/tab and 2.044 mg/tab respectively. Percentage recoveries obtained forrisperidone and trihexyphenidyl hcl in sizodon plus were 100.87% and 102.49%respectively, percentage recoveries obtained for risperidone andtrihexyphenidyl hcl in RI-plus were 100% and 101.65% respectively.  The proposed method is accurate, precise,selective and rapid for the simultaneous estimation of risperidone andtrihexyphenidyl hydrochloride in tablet dosage.

Key words:  HPLC, Validation, Risperidone,Trihexyphenidyl hydrochloride


Article outline

1.Introduction

2.HPLC method development

3.assay,linearity study,accuracy,system suitability

4.Results and discussion



Typical HPLC Chromatogram of Risperidone &  Trihexyphenidyl Hcl


For Correspondence: sdraj1979@gmail.com 

Contact09951424683

© 2011  Hygeia journal for drugs andmedicinesall rights reserved.  2229 3590, 0975 622

Hygeia J. D. Med.





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