Hygeia.J.D.Med.9(1) July 2017 - December 2017

Abstract

ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES OF THE METHANOLIC EXTRACTS OF THE STALK OF Parkia biglobosa (JACQ.) BENTH.
Hygeia J. D. MedVol.3 (1) April 2011- September 2011,34-40 .

Type of Article: Research article
Authors : 
Nwaehujor C.O.1*, Ezeigbo I. I.2,Udeh N. E.2, Ezeja M.I. 2 and AsuzuI. U.3

Affiliations
:

           1. Department ofBiochemistry, University of Nigeria, Nsukka.

           2. Department of VeterinaryPhysiology and Pharmacology, Michael Okpara University of Agriculture, Umudike,

           3 .Department of VeterinaryPhysiology and Pharmacology, University of Nigeria, Nsukka.

    

    Article history: Received: 10 October, 2010,revised: 12 November, 2010, accepted: 13 January, 2011, Available online: 14 April 2011

   Abstract

 

  Oral administration of  various doses (50, 100and 250 mg/kg) of the methanol extracts of the stalk of Parkia biglobosa produced anti-inflammatory activities by reducing the croton oil ear inflammation, though not statistically relevant at p<0.01 level of significance. It also antagonised the oedema produced by carrageenin and arachidonic acid as well as the granuloma by cotton pellet in rats. The stalk also showed in vitro anti-oxidant activities using the DPPH. The extractis suspected to produce its anti-inflammatory activity by inhibiting both the lipo-oxygenase and cyclo-oxygenase pathways of the arachidonic acid metabolism.

 

      Key words: Anti-inflammatory, Anti-oxidant, Parkia biglobosa  


     Article outline:


1.  Introduction
2.  Extraction
3.  Anti inflammatory activity
4.  Anti oxidant activity
6.  References









For Correspondence: chinaka_n@yahoo.com (C.O. Nwaehujor)

 © 2010 Hygeia journal for drugsand medicines

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Hygeia J. D. Med.





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