Hygeia journal for drugs and medicines


A Review of Biological potential of Pyrazinamide derivatives
Hygeia.J.D.Med.4(1),April 2012-October 2012,1-6.

Vikramjeet Judge1, Balasubramanian Narasimhan2*, Munish Ahuja1


1. Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, India

2. Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.

Article history: 

Received: 29 Nov., 2011,

Revised: 2 December, 2011,

Accepted: 15 December 2011

Available online: 05April 2012


Plan: A review on the importance of pyrazinamide derivatives for the treatment of tuberculosis

PrologueTuberculosis is a chronic granulomatous disease and a major health problem in developing countries. Pyrazinamide (PZA) is an important front-line drug for the treatment of tuberculosis (TB). Pyrazinamide, along with isoniazid and rifampicin, forms the cornerstone of modern TB therapy. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either to an altered target or to a change in titration of the drug. The problem of resistance demand to search and synthesize new classes of compounds effective against pathogenic microorganisms that have developed resistance to the drugs used in the current regimen.

Outcome: In the present study, we have made an attempt to compile the reports on biological potential of pyrazinamide and its derivatives. The pyrazinamide derivatives possess unexplored potential that can be utilized for the development of new chemical entities (NCEs) to treat the mycobacterial infections.  

KeywordsPyrazinamide (PZA), Antimycobacterial, Antimicrobial, Antibacterial, Antifungal    

Article out line


2.Strategies employed for the synthesis of pyrazinamide derivatives


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