Hygeia journal for drugs and medicines


A Sensitive Spectrophotometric method for the Quantitative Determination of Buspirone Hydrochloride in Pharmaceutical Formulations

Hygeia.J.D.Med.4 (1), April2012-October 2012,63-68

Authors: Jose Kurien* and Thomas Kurian

Affiliations:College of Pharmaceutical Sciences, Govt. MedicalCollege, Kottayam, Kerala, India-686 008.

Article history:

Received:29 November, 2011,

 Revised: 20 December 2011,

Accepted:3 February 2012,

Availableonline: 5 April 2012



Plan: An analytical method forthe estimation of Buspirone hydrochloride in bulk drug and tablet formulationis described.

Methodology: Thedeveloped method is based on the formation of red colored chromogen due to thereaction of Buspirone hydrochloride with Thiobarbituric acid reagent, whichexhibits λmax at 531nm against reagent blank. The color was stable for morethan 6 hrs for method. Beer’s law is obeyed over the concentration range of 10-100μg /ml. All the variables were studied to optimize the reaction conditions. Thecalculated molar absorptivity value is 2.29 × 106 lit.mol-1.cm-1.

Outcome: Theproposed method was successfully applied to the determination of Buspironehydrochloride in formulations. Good recoveries were obtained and the resultswere statistically compared with the official method, showed good agreement andindicated no significant difference in precision. No interference was observedin the presence of common pharmaceutical excipients. The proposed method doesnot require any extraction.

KeyWords: Buspirone Hydrochloride, Thiobarbituricacid, Spectrophotometric method.


Article outline:

1. Intorduction

2. Study protocol

3. Results and discussion

4. Conclusion



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For correspondence:josekurien@hotmail.com

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