Hygeia journal for drugs and medicines


Whitening and Antierythemic effect of a cream containing Morus alba extract

Hygeia.J.D.Med.4 (1), April2012-October 2012, 97-103

Authors: NaveedAkhtar1, Jehad Hisham1, Haji M. Shoaib Khan1,Barkat Ali Khan1*, TariqMahmood1 and Tariq Saeed 2                   


1. Departmentof Pharmacy, Faculty of Pharmacy and Alternative Medicine, The IslamiaUniversity of Bahawalpur, Pakistan.

2.College of Pharmacy, University of the Punjab, Lahore, Pakistan.


Plan: To determine the effects of a  newly formulated w/o emulsion (cream) of the ethanolicextract of  mulberry fruits(Morus alba) withits vehicle (Base) as control on skin melanin, skin erythema and skin moisture content.

Methodology: Concentrated 4% Mulberry fruit extract was entrapped in the inner aqueous phaseof w/o emulsion. The newly formulatedbase and formulation were applied to the cheeks of undiseased human volunteersfor a period of 8 weeks. Melanin,erythema and skin moisture were monitored every week and analyzed by Mexameterand Corneometer. Statistically the results of both base and formulation werecompared by using ANOVA and Paired t test.

Outcome: The baseshowed insignificant (p> 0.05) effects while the formulation showedstatistically significant (p≤0.05) decrease in melanin content. Both the baseand formulation showed insignificant (p> 0.05) effects on skin moisturecontent. Skın erythema was significantly (p≤0.05)  reduced by the formulation.This formulation of cream containing 4% concentrated extractof mulberry can be used for skin whitening as it can decrease skin melanincontent. Furthermore, the decrease in erythema showed that the cream will besafe to use and will not cause any irritation. 

Key wordsMorusalba , Melanin, Erythema, Mexameter, Corneometer.


 Received: 25December, 2010,

 Revised: 23 February, 2011,

Accepted:11 September, 2011,

Availableonline: 5 April 2012



Article outline:

1. Intorduction

2. Materials and Methods

3. Results and discussion



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For Correspondencebarki.gold@gmail.com
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