Hygeia J. D.Med.9 (2) January 2018 - July 2018

Abstract

Synthesis and Antimicrobial screening of some Novel Substituted Thiophenes

Hygeia.J.D.Med.4 (1), April2012-October 2012, 112-118

Authors: Mohammad Asif Iqbal C 1, Satyendra D 2*,Apurba T 2, Patel M1, Monika K1, GirishK 1, Mohan S 1, Saravanan J 1

Affiliations:

   1. Department of Pharmaceutical Chemistry, PES College ofPharmacy, Hanumanthnagar, Bangalore, Karnataka, India

 2.Assam down town University, Dept. of Pharmacy, Panikhati, Guwahati-26, Assam,India.

 

Articlehistory:

Received: 10 February, 2012,

Revised: 23 February, 2012,

Accepted: 10March, 2011,

Available online: 5 April 2012

Abstract

Plan: To synthesize some novel2-amino thiophenes with various substitutions at 2-amino position for antibacterialand antifungal activity.

Prologue: Thiophenes containing organic compounds forms a significant group ofdrugs which exhibit an array of biological activities like anti-inflammatory,antibacterial, antifungal, anti-neoplastic, antiarthritic etc. Thus a series of new thiophenes havesynthesized with various substituents at 2-amino position and screened forantimicrobial activity.

Methodology: The parentcompound 2-amino-3-(N-furfuryl amido)-4, 5-dimethyl thiophene was synthesizedby condensing butan-2-one with furfurylcyano acetamide in presence of sulphurand diethylamine. It was then derivatized to various Schiff bases by reactingwith various substituted aromatic aldehydes. The synthesized new compounds werecharacterized by MP, TLC, IR, NMR and Mass spectra and were screened for theirantibacterial and antifungal activity by using Ampicillin and Miconazolenitrate as standard respectively.

Outcome: The compounds MAI-2e, MAI-2k, & MAI-2l showed potent antibacterialand MAI-2a, MAI-2c, MAI-2e, & MAI-2fshowed potent antifungal activity.

Keywords:  2-amino thiophenes,Schiff bases, Antimicrobial activity, S.aureus, B.subtilis, E.coli, K.pneumoniae


Article outline:

1. Intorduction

2. Experimental

3. Results and discussion

 

 

For downloading full text articles and issues in PDF, at free of cost , you have to  fillup the hygeia registration form.  At any time, you may request for the removal of yourcontact information from our website database.

 

 

For correspondence:

harekrishnaks@yahoo.com.

Contact:mobile: 0091 9706602852 

http://www.researcherid.com/rid/C-3213-2012

               

 

© 2011 All rights reserved.  2229 3590, 0975 6221

 

 

Hygeia J. D. Med.





Videos

  • watch Video
    Collagen Mimetic Peptides
  • watch Video
    Mechanisms and secrets of Alzheimer's disease...
  • watch Video
    Immunotherapy to fight cancer
  • watch Video
    Food Safety Emergency Prevention
  • watch Video
    Tiny worm-like robot could deliver medicine inside body
  • watch Video
    This smart pill could crawl through your body to deliver its medicine
  • watch Video
    Introduction To Nanorobotics: A conversation