Hygeia.J.D.Med.9(1) July 2017 - December 2017

Abstract

Evaluation of Anti-inflammatory activity of acid Hydrazide derivatives

Rakesh Narang1,Sunil Sharma1, Balasubramanian Narasimhan2*

1.Department of Pharmaceutical Sciences, Guru Jambheshwar University of Scienceand Technology, Hisar 125001, India.

2. Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India.

Article history: Received: 20 June 2012,  revised: 17 August 2012, accepted:26 August 2012, Available online:10October 2012

Page:15-20

Abstract

Plan: Anti-inflammatory evaluation of acid hydrazide derivatives.

Prologue: Hydrazide derivatives of organic compounds forms a significant group of derivatives which exhibit an arrayof biological activities like anti-inflammatory, antibacterial, anti fungal,anti-neoplastic, antiviral etc. In view of above facts, we hereby reported the anti-inflammatory evaluation of selected most active eight antimicrobial acid(nicotinic acid, naphthalene-1-acetic acid and 2-naphthoxy acetic acid)hydrazide derivatives.

Methodology: The anti-inflammatory activity of reported hydrazide derivatives determined by carrageenan induced paw oedema method and diclofenac sodium as standard drug.

Outcome: Anti-inflammatory activity showed that nicotinic acid hydrazide derivatives with NOsubstituents at ortho and meta position were the most active ones among the selected hydrazide derivatives, having 35.73% and 37.29%; 25.12% and 34.17%inhibition, at two different doses 20 mg/kg and 50 mg/kg b.w., respectively.

Keywords: Anti-inflammatory,Antimicrobial, Acid hydrazides

How to site this article:Rakesh Narang, Sunil Sharma ,Balasubramanian Narasimhan . Evaluation of Anti-inflammatory activity of acid Hydrazide derivatives.Hygeia.J.D.Med 2012;4(2) :15-20.

How to site this URL:Rakesh Narang, Sunil Sharma ,Balasubramanian Narasimhan . Evaluation of Anti-inflammatory activity of acid Hydrazide derivatives.Hygeia.J.D.Med 2012;4(2) :15-20.available from:http://www.hygeiajournal.com/Abstract.aspx?did=161

For Correspondence:
 E-mail: naru2000us@yahoo.com
Phone No: +91-1262-272535;

 Fax:+91-1262-274133.
Hygeia.J.D.Med.Vol.4 (2), Oct. 2012
© 2012, Hygeia journal for drugs and medicines, all rights reserved.  2229 3590, 0975 6221 

Hygeia J. D. Med.





Videos

  • watch Video
    Collagen Mimetic Peptides
  • watch Video
    Mechanisms and secrets of Alzheimer's disease...
  • watch Video
    Immunotherapy to fight cancer
  • watch Video
    Food Safety Emergency Prevention