Hygeia journal for drugs and medicines


Antipsoriatic activity and Cytotoxicity of ethanolic extract of Psoralia corylifolia seeds

L. Priyanka Dwarampudi , Dhanabal SP*, Shanmugam R , Muruganantham N

1. Department of Phytopharmacy and Phytomedicine (TIFAC CORE HD), JSS College of Pharmacy, Rocklands, Ooty 643001,India.
2 .Department of Pharmaceutical Analysis, JSS College of Pharmacy, Rocklands, Ooty 643001, India.

Article history: Received: 27 June 2012,   revised: 11 August 2012,accepted: 21 August 2012, Available online: 10 October 2012



Plan: Traditionally in India and China, Psoralia corylifolia seed decoction used for treating psoriasis. However, the antipsoriatic activity of Psoralia corylifolia seeds has not been scientifically evaluated using mouse tail model.

Methodology:  Ethanolic extract of Psoralia corylifolia seeds were analyzed  by high performance thin layer chromatography (HPTLC) .The In vivo antipsoriatic activity of 95% of ethanolic extract of Psoralia corylifolia seeds was done by using mouse tail model for psoriasis and In vitro antipsoriatic activity  was carried out by Sulphorhodamine B (SRB)assay using HaCaT human keratinocyte cell lines.

Outcome: HPTLCfingerprinting revealed the presence of gallic acid. The ethanolic extractshown IC50 255 μg/ml, with goodantiproliferant activity when compared with Asiaticoside as positive controlwith potent IC50 value of 20.13 μg/ml.Psoralia corylifolia seed extract showed an overall antipsoriatic activityof 75.87%, when compared with standard tazarot gel activity 87.94%   by using mouse tail model, confirmed itstraditional use in psoriasis treatment.

Keywords: Psoralia corylifolia, Antipsoriatic activity, Cytotoxicity, SRB Assay,Mouse tail model.

For Correspondence:  

E-mail: dhanabalsp@rediffmail.com

Phone: +91 423 2443393, 2443647,2443847,

 Fax: +91 423 2442937

Hygeia.J.D.Med. Vol.4 (2), Oct.2012

© 2012, Hygeia journal for drugs and medicines, allrights reserved.  22293590, 0975 6221



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