Hygeia journal for drugs and medicines


Wound healing activity studies of Wrightia arborea Phytosome in rats

S. Lakshmi Devi* and Madhu.C. Divakar   

1. Department of Pharmacognosy, Sri Ramakrishna College of Pharmacy, SRIPMS, Coimbatore, Tamil Nadu -, 641 044, India.

2. Crescent College of Pharmaceutical Sciences, Payangadi R.S. Post, Kannur, Kerala-670 358, India.

Article history: Received: 24 May 2012,   revised:10 June 2012, accepted:12 July 2012, Available online:10 October 2012


Plan: The study was aimed to evaluate the wound healing activity of 70% ethanolic extract (WAET) of the leaves of Wrightia arborea (Apocynaceae) and the phytosome (WAP) prepared out from WAET using incision and excision wound models on wistar albino rats.

MethodologyWound contraction and epithelization period were assessed in excision wound model whereas wound tensile strength was determined in the case of incision wound model.

Outcome: The Wrightia arborea phytosome (WAP 4%) exhibited significant wound healing potential when compared to WAET and standard 0.2% Nitrofurazone Ointment.

Keywords: Wrightia arborea leavesIncision andExcision wounds, Tensile strength, Epithelization period, WAP, WAET

For correspondence ldevijp@yahoo.co.in 

Contact: mobile: 0091 9047034536


Hygeia.J.D.Med.Vol.4 (2), Oct. 2012

© 2012, Hygeia journalfor drugs and medicinesall rights reserved.  2229 3590, 0975 6221


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