Abstract
Wound healing activity studies of Wrightia arborea Phytosome in rats
S. Lakshmi Devi* and Madhu.C. Divakar
1. Department of Pharmacognosy, Sri Ramakrishna College of Pharmacy, SRIPMS, Coimbatore, Tamil Nadu -, 641 044, India.
2. Crescent College of Pharmaceutical Sciences, Payangadi R.S. Post, Kannur, Kerala-670 358, India.
Article history: Received: 24 May 2012, revised:10 June 2012, accepted:12 July 2012, Available online:10 October 2012
Abstract
Plan: The study was aimed to evaluate the wound healing activity of 70% ethanolic extract (WAET) of the leaves of Wrightia arborea (Apocynaceae) and the phytosome (WAP) prepared out from WAET using incision and excision wound models on wistar albino rats.
Methodology: Wound contraction and epithelization period were assessed in excision wound model whereas wound tensile strength was determined in the case of incision wound model.
Outcome: The Wrightia arborea phytosome (WAP 4%) exhibited significant wound healing potential when compared to WAET and standard 0.2% Nitrofurazone Ointment.
Keywords: Wrightia arborea leaves, Incision andExcision wounds, Tensile strength, Epithelization period, WAP, WAET
For correspondence: ldevijp@yahoo.co.in
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researcherid.com/rid/C-3285-2012
Hygeia.J.D.Med.Vol.4 (2), Oct. 2012
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