Hygeia.J.D.Med.9(1) July 2017 - December 2017

Abstract

Critical assessment pertaining to Gastric Floating Drug Delivery Systems

Hygeia.J.D.Med. 2013;5(1):41-58

Vinod KR*, Gangadhar M, Sandhya S, David Banji

Nalanda College of Pharmacy, Nalgonda, A.P. 508001, India; affiliated to Osmania University, Hyderabad,Andhra Pradesh, India.

Article history: Received: 21 December 2012,   revised: 2 February 2013, accepted: 18February2013, Available online: 3 April 2013

Abstract

Plan: This review discusses overall approaches of gastro retentive drug delivery systems and limelight on floating drug delivery ,its formulation development and discusses various evaluation parameters.

Preface: Oral drug delivery of nearly half of the drugs gets thwarted owing to the high lipophilic nature .Bioavailability of these drugs being function of their aqueous solubility and dissolution tends to exhibit low magnitude and high intra and inter subject variability. Many drugs have a short biological half life and thus have invents potential in ameliorating GI absorption. To overcome the poor bioavailability and patient complaints much attention has been given to Gastro retentive drug delivery system,although there are various approaches in retaining the drug within the gastric region.

Outcome: Floating dosage form can be broadly divided into effervescences and non effervescences both have its own merits and demerits.To state that a given floating drug delivery system successfully float ,its lagtime should be within 5 min. Factors affecting floatation are size, shape,density, single or multiple unit, fed or unfed state, nature and frequent offood, gender, age, patient related etc. Evaluation include buoyancy study,floating and swelling behavior, drug release in additional to conventional evaluation, in vivo evaluation is important since the results may not adequately correlate with in vitro results. The usual reported in vivo floatation studies include x-ray, gamma scintigraphy, gastroscophy, magneticmarker, ultrasonography and octanoic acid breath test. 

Key words: gastro retention, buoyancy, mucoadhesive, transit time,scintigraphy

Vinod KR,Gangadhar M, Sandhya S, David Banji. Critical assessment pertaining to Gastric Floating Drug Delivery Systems.Hygeia.J.D.Med. 2013; 5(1): 41-58.  Available from  http://www.hygeiajournal.com /Article ID- Hygeia.J.D.Med/87/13

 

For Correspondence: vinodkrpharm@gmail.com
 Hygeia.J.D.Med.Vol.5 (1), April 2013

©2013, Hygeia journal for drugs and medicines,
All rights reserved.  2229 3590, 0975
6221

Researcher ID: C-3691-2012

Hygeia J. D. Med.





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