Abstract
Simple Spectrophotometric determination of Tegaserod Maleate in Pharmaceutical dosage forms
Hygeia.J.D.Med. 2013; 5(1):59-62.
Helen William*, Bijumol C, Jose Kurien and Thomas Kurian
College of Pharmaceutical Sciences, Govt. Medical College, Kottayam, Kerala
Article history: Received: 22 December 2012, revised: 12 January 2013, accepted: 2 February 2013, Available online: 3 April 2013
Abstract
Plan: An analytical method for the estimation of Tegaserod Maleate in bulk drugs and pharmaceutical dosage forms is described.
Prologue: Tegaserod Maleate is the first selective serotonin 5-HT4 receptor partial agonist to improve symptoms of constipation-predominant Irritable Bowel syndrome. The present study aims at the development of simple Spectrophotometric method for the estimation of Tegaserod in dosage forms.
Methodology: The developed method is based on the formation of a purple coloured complex due to the reaction of Tegaserod Maleate with p-Dimethylaminobenzaldehyde reagent, which gave a maximum absorbance at 515 nm.Beer’s law is obeyed over the concentration range of 5-50µg/ml. All the variables were studied to optimize the reaction conditions.
Outcome: The proposed method is simple, fast, accurate and economical and can be used for the routine analysis of Tegaserod in dosage forms.
Keywords: Tegaserod Maleate, p-Dimethylaminobenzaldehyde,Spectrophotometric method
Helen William, Bijumol C, Jose Kurien and Thomas Kurian. Simple Spectrophotometric determination of Tegaserod Maleate in Pharmaceutical dosage forms. Hygeia.J.D.Med. 2013; 5(1):59-62.Available from http://www.hygeiajournal.com /Article ID- Hygeia.J.D.Med/88/13.
For Correspondence: helenwilliam2012@ymail.com
Hygeia.J.D.Med. Vol.5 (1), April 2013
© 2013, Hygeia journal for drugs and medicines,
All rights reserved. 2229 3590, 09756221
Researcher ID: J-8343-2012