Anti-inflammatory effect of Abyssinone V-4'-methyl ether on acute and chronic inflammation models
Hygeia.J.D.Med. 2013; 5(1):121-128
S.D. Sokeng1*, E. Talla2,V. Jeweldai1, A.J.G Yaya3, J. Koube1, F.Dongmo1, M.Goulimé1, J.T. Mbafor4
1. Department of Biological Science, Faculty of Science, University of Ngaoundere, Cameroon
2. Department of Chemistry, Faculty of Science, University of Ngaoundere, Cameroon
3. Medical and Medicinal plants Institute (IMPM), Yaounde, Cameroon
4. Department of Organic Chemistry,University of yaounde1, Cameroon
Article history: Received: 29 January 2013, revised: 20 February 2013, accepted: 5 March 2013, Available online: 3 April 2013
Plan:Anti-inflammatory evaluation of abyssinone V-4’-methyl ether.
Prologue: The anti-inflammatory activity of abyssinone V-4'-methyl ether, a natural prenylated flavonoid isolated from the bark of Erythrina droogmansiana (Leguminosae) was evaluated using acute and chronic inflammation models in vivo namely carrageenan-induced paw edema in rats, xylene induced-ear edema in mice and cotton pellets-induced granuloma formation in rats.
Methodology: Oral administration of abyssinoneV-4'-methyl ether at doses of 2.5, 5 and 10 mg/kg produced a dose-related inhibition of edema formation in the carrageenan induced-paw edema test inrats.
Outcome: The highest dose (10 mg/kg) of the compound induced an inhibition of 71.43% compared to 61.90% inhibition obtained with dexamethasone (2.5 mg/kg). In the xylene induced-ear edema in mice, abyssinone V-4'-methyl ether also produced a dose-dependent effect with a maximum inhibition of 62.25% obtained with the dose 10 mg/kg. In the chronic test, abyssinone V-4'-methyl ether at similar doses strongly inhibited the granulomatous tissue formation in cotton pellet-induced granuloma model inrats. These results suggest the anti-inflammatory properties of abyssinoneV-4'-methyl ether. This is the first time that the anti-inflammatory activity of this prenylflavanone is reported.
Keywords: Abyssinone V-4'-methyl ether,anti-inflammatory activity, carrageenan-induced paw edema, xylene induced ear edema, cotton pellet-induced granuloma.
D. Sokeng, E. Talla, V. Jeweldai,A.J.G Yaya, J. Koube, F. Dongmo, M.Goulimé, J.T. Mbafor. Anti-inflammatory effect of abyssinone V-4'-methyl ether on acute and chronic inflammation models.Hygeia.J.D.Med. 2013; 5(1):121-128. Available at http://www.hygeiajournal.com / Article ID- Hygeia.J.D.Med/96/13
For Correspondence: email@example.com ,
Contact: +23774959223 (Dr S. D. Sokeng)
Hygeia.J.D.Med. Vol.5 (1), April 2013
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