Evaluation of Phoenix dactylifera fruits for Antiurolithiatic activity
Hygeia.J.D.Med. 2013; 5(1):135-140
Challa Srinivas Reddy*, Pradeep Vardhaman
VaagdeviCollege of Pharmacy,Hanamkonda, Warangal, Andhra Pradesh., India.
Article history: Received: 5 January 2013, revised: 20 January 2013, accepted: 15February 2013, Available online: 3 April 2013
Materials and Methods: Then-Butanol and Aqueous extract preparations were made and administered as test compounds,Cystone as reference standard in five groups. Ethylene glycol induced hyperoxaluria is selected as a screeningmethod for induction of kidney stones and the levels of creatinine, urea and uricacid are analysed.
Outcome: The n-butanol and aqueous extracts of P. dactylifera fruits in the doses of 200 mg/kg reduced creatinine, urea, uric acid levels,significantly in comparison with the control. But both the extracts showed results less than the standard drug 'Cystone' and the n-butanol extract was more effective than aqueous extract to decrease urea and uric acid levels.Among these two extracts the n-butanol extract exhibited more antiurolithiatic activity.
Keywords: Phoenix dactylifera, Ethylene Glycol, Urea, Uric Acid,Antiurolithiatic Activity.
ChallaSrinivas Reddy, Pradeep Vardhaman .Evaluation of Phoenix dactylifera fruits for Antiurolithiatic activity. Hygeia.J.D.Med. 2013; 5(1):135-140.Available at http://www.hygeiajournal.com / Article ID- Hygeia.J.D.Med/98/13
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Hygeia.J.D.Med. Vol.5 (1), April 2013
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Researcher ID: K-5130-2012A