Evaluation of a dermatological herbal hydrogel integrated with Ipomea pes-tigridis for anti acne activity
Hygeia.J.D.Med.5 (2) 1-12.
S. Sandhya*, E. Vidya Sravanthi, K.R Vinod
Department of Pharmacognosy, Nalanda College of Pharmacy, Cherlapally,Nalgonda-508001, Andhra Pradesh, India.
Article history: Received: 10 May 2013, revised:4 June 2013, accepted: 15July 2013, Available online: 3 October 2013
Plan: The objective of this research investigation was to formulate and evaluate herbal hydrogel incorporated with the extract of Ipomea pes-tigridis intended for anti acne activity.
Methodology: The formulation was evaluated for various parameters like organoleptic characters, pH, skinirritation test by multiple compartment patch, microbial contamination, extrudeability, spread ability, drug content, diffusion studies using pig skin,accelerated stability studies, drug excipient interaction studies by FTIR, invitro anti acne and in vivo anti inflammatory activity.
Outcome: The formulated hydrogel passed all the evaluation parameters. The hydrogel was olive green in colour and had an excellent fragrance. The diffusion studies revealed that the drugrelease was in controlled release form. The accelerated stability studies revealed that formulation was stable at room temperature whereas its stability reduced with increase in temperature. The FTIR studies showed that there were no drug excipient interactions. The anti acne and anti inflammatory activity showed an activity comparable to that of the standard drugs clindamycin and diclofenac,respectively. Hence it can be concluded that the formulation can be a good substitute for the existing synthetic anti acne agents.
Keywords: Carbopol 940, Propionibacterium acnes, Staphylococcus aureus, acne vulgaris.
S. Sandhya, E. Vidya Sravanthi, K.R Vinod. Evaluation of a dermatological herbal hydrogel integrated with Ipomea pes-tigridis for anti acne activity, Hygeia.J.D.Med. 2013; 5(2):page.1-12 , Available from http://www.hygeiajournal.com /Article ID- Hygeia.J.D.Med/103/13
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Multiple compartment Patch test for skin irritation