Hygeia journal for drugs and medicines


Antiulcer activity of Rheum emodi

Hygeia.J.D.Med.5 (2) 13-20.

Amandeep Kaur, Ramica Sharma*, SunilKumar

Department of Pharmacology, Rayat Institute of Pharmacy, Railmajra,S. B. S Nagar. Punjab, India- 144514

Article history:Received: 22 December 2012,   revised:17 May 2013, accepted: 2 June 2013, Available online: 3 October 2013  

Article ID- Hygeia.J.D.Med/104/13



Plan: The present study was designed to investigate the antioxidant andgastroprotective potential of ethanolic extract of Rheum emodi.

Methodology: Antioxidant and gastroprotective activity was evaluated usingreserpine and ethanol-induced ulcer models. The ethanolic extract of the Rheumemodi (EERE) was given by oral route at a dose of 50 mg/kg/p.o. and 100 mg/kg

Outcome:  Pre-treatment with EERE, dosedependently reduced the ulcer index and lesions with marked attenuation in thelevel of oxidative stress parameters estimated by TBARS, GSH, SOD and MPO. EEREadministration increases the gastric adhesion mucus content in ethanol andreserpine-induced ulcer.

Keywords: Antioxidant Activity, gastroprotective activity, ethanolic extract ofRheum emodi

Amandeep Kaur, Ramica Sharma, Sunil Kumar. Antiulcer activity of Rheum emodi. Hygeia.J.D.Med. 2013; 5(2): page.13-20 Available from   http://www.hygeiajournal.com

For Correspondence: ramicasharma@yahoo.com
Contact: +91-9815520843 ,
Researcher ID: G-9629-2012   

Effect of Rheum emodi on gastric mucosal injury
 integrity in reserpine-induced ulceration.


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