Abstract

Evaluation of Anticonvulsant Activity of the Seed Oil Extract of Nigella sativa: an Experimental study.
Hygeia.J.D.Med.5 (2) 21-26

Swapnil C Jaykare* , Vijay M Motghare ,Sudhir L Padwal, Vinod S Deshmukh , Jyoti R Patil , Harshal N Pise , and  Rakesh R Pore

Dept of Pharmacology, S.R.T.R. Government Medical College,Ambajogai, Beed District, State: Maharashtra 431517, India.

Article ID- Hygeia.J.D.Med/105/13

ABSTRACT

Plan: The present study was carried out to evaluate anticonvulsant activity of Nigella sativa oil in Pentylenetetrazol (PTZ) and Maximal electroshock (MES) induced seizures in mice.

Methodology: The anticonvulsant activity of Nigella sativa oil at dose of 10 mg/kg/p.o. was evaluated in mice by using electroshock and PTZ seizure methods. The standard was taken as Phenytoin for electroshock method and Diazepam for PTZ method.

Outcome: In PTZmodel Nigella sativa showed statistically significant protection in increasingthe latency of convulsions (p value 0.030). While in MES model though there wasdecrease in the duration of tonic hind limb extension but it was notstatistically significant.

Conclusions: Nigellasativa has shown anticonvulsant activity in PTZ model, which is suggestive ofits potential benefit in petit mal type of epilepsy and hence there is need totest it in various other animal models.

Keywords: Nigella sativa, Maximalelectroshock (MES), Pentylenetetrazol (PTZ), Seizures.

Swapnil C Jaykare* , Vijay M Motghare , Sudhir L Padwal, Vinod S Deshmukh , Jyoti R Patil , Harshal N Pise , and  Rakesh R Pore.Evaluation of Anticonvulsant Activity of the Seed Oil Extract of Nigella sativa: an Experimental study Hygeia.J.D.Med. 2013; 5(2): page.21-26. Available from   http://www.hygeiajournal.com