The Anti-diabetic, Hypolipidemic and Anti-oxidant activities of D-3-O-methylchiroinositol in alloxan-induced diabetic rats.
Hygeia.J.D.Med.5 (2) 27-33
Isaac U. Asuzu* and Chinaka O. Nwaehujor
Department of Veterinary Physiology and Pharmacology, University ofNigeria, Nsukka, Nigeria.
Article history: Received: 30 July 2013, revised: 5 August 2013, accepted: 10 August2013, Available online: 3 October 2013
Article ID- Hygeia.J.D.Med/106/13.
Plan: The anti-diabetic and anti-hyperlipidemic effects of D-3-O-methylchiroinositol were investigated in male Wistar rats.
Methodology: Diabetes was induced by a single intra-peritoneal injection of 150 mg/kg of alloxanmonohydrate. Five groups of rats comprising six animals in each group were used including a positive control group (glibenclamide, 2 mg/kg), treatment groups (8,4 and 2 mg/kg of D-3-O-methylchiroinositol respectively) and control(untreated) group. Blood samples were obtained from the rat tails every morning before treatment.
Outcome: Alloxan-induced hyperglycaemia was significantly (p< 0.05) reduced by 59%, 48% and 41% after four days at 8, 4 and 2 mg/kg respectively compared with the untreated group(-135%) and Glibenclamide (50%). The in vitro anti-oxidant assays (DPPH andFRAP) showed that D-3-O-methylchiroinositol increased anti-oxidant activities with increasing concentration (10 – 400 μg/ml).D-3-O-methylchiroinositol therefore has anti-diabetic hypolipidemic and anti-oxidant activities.
Keywords: D-3-O-methylchiroinositol;diabetes; hyperglycemia; cholesterol; DPPH; FRAP.
Isaac U. Asuzu* and Chinaka O. Nwaehujor. The Anti-diabetic, Hypolipidemic and Anti-oxidant activities of D-3-O-methylchiroinositol in alloxan-induced diabetic rats. Hygeia.J.D.Med. 2013; 5(2): page.27-33. Available from http://www.hygeiajournal.com
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