Hygeia.J.D.Med.9(1) July 2017 - December 2017

Abstract

The Anti-diabetic, Hypolipidemic and Anti-oxidant activities of D-3-O-methylchiroinositol in alloxan-induced diabetic rats.


Hygeia.J.D.Med.5 (2) 27-33

Isaac U. Asuzu* and Chinaka O. Nwaehujor


Department of Veterinary Physiology and Pharmacology, University ofNigeria, Nsukka, Nigeria.
 
Article history: Received: 30 July 2013,   revised: 5 August 2013, accepted: 10 August2013, Available online: 3 October 2013
 

Article ID- Hygeia.J.D.Med/106/13.

ABSTRACT

Plan: The anti-diabetic and anti-hyperlipidemic effects of D-3-O-methylchiroinositol were investigated in male Wistar rats.

Methodology: Diabetes was induced by a single intra-peritoneal injection of 150 mg/kg of alloxanmonohydrate. Five groups of rats comprising six animals in each group were used including a positive control group (glibenclamide, 2 mg/kg), treatment groups (8,4 and 2 mg/kg of D-3-O-methylchiroinositol respectively) and control(untreated) group. Blood samples were obtained from the rat tails every morning before treatment.

Outcome: Alloxan-induced hyperglycaemia was significantly (p< 0.05) reduced by 59%, 48% and 41% after four days at 8, 4 and 2 mg/kg respectively compared with the untreated group(-135%) and Glibenclamide (50%). The in vitro anti-oxidant assays (DPPH andFRAP) showed that D-3-O-methylchiroinositol increased anti-oxidant activities with increasing concentration (10 – 400 μg/ml).D-3-O-methylchiroinositol therefore has anti-diabetic hypolipidemic and anti-oxidant activities. 

Keywords: D-3-O-methylchiroinositol;diabetes; hyperglycemia; cholesterol; DPPH; FRAP.


Isaac U. Asuzu* and Chinaka O. Nwaehujor. The Anti-diabetic, Hypolipidemic and Anti-oxidant activities of D-3-O-methylchiroinositol in alloxan-induced diabetic rats. Hygeia.J.D.Med. 2013; 5(2): page.27-33. Available from   http://www.hygeiajournal.com



For Correspondence: 
iasuzu@yahoo.ie,
Rid: H-6094-2013



D-3-O-methylchiroinositol 

Hygeia J. D. Med.





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