Abstract

Formulation and in-vitro Evaluation of oral Floating Nicardipine hydrochloride Tablets

Hygeia.J.D.Med.5 (2) 63-75

Chabria Neetu. B.1*   N. Narayanan.2

1. Pharmacy Department, Higher College of Technology, Ministry of Manpower, Muscat, Sultanate of Oman.

2. Department of Pharmaceutics, Jaya College of Pharmacy, Thiruninravur, Chennai, TamilNadu, India.

Article history: Received: 27 May 2013,   revised: 19 June 2013, accepted: 12 July 2013, Available online: 3 October 2013

Article ID- Hygeia.J.D.Med/110/13.

ABSTRACT

Plan: The purpose of this research was to develop floating matrix tablets of Nicardipine HCl (NIC) using different viscosity grades of direct compressible polymers with gas generating agent so as to prolong its gastric residence time.

Preface: Rapid gastrointestinal transit could lead to incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose.

Methodology: The tablets were prepared by direct compression technique. Precompressional and post compressional parameters were evaluated. In vitro dissolution studies were carried out in gastric acid fluid (pH 1.2). The mechanism of drug release from matrix tablets were analyzed kinetically using zero order, first order, Korsmeyer peppas, Higuchi and hixon Crowell models.

Outcome: The FTIR studies revealed no interaction between the drugs and excipients. F7 with R² value 0.9965 was considered optimized formulation with short floating lag time and long floating duration and release over 24h duration.

Key words: Floating tablet; dissolution; Nicardipine HCl; HPMC; kinetic models.

ChabriaNeetu. B*   N. Narayanan. Formulation and in-vitro Evaluation of oral Floating Nicardipine hydrochlorideTablets. Hygeia.J.D.Med.2013; 5(2): page.63-75. Available from  http://www.hygeiajournal.com/ Article ID- Hygeia.J.D.Med/110/13.

The SEM microphotograph of formulation F7

FTIR studies on formulation F7