Synthesis and in-vitro Anti-platelet aggregation activity of some New substituted Thiophenes
Hygeia.J.D.Med.5 (2) 87-96
Jagadish ER1, Mohan S1, Saravanan J1, Satyendra D2*, Swetha Sree P1, Apurba T2, Manoj K3, Rama Kanta S4
1. Department of Pharmaceutical Chemistry, PES College of Pharmacy, Hanumanth nagar, Bangalore, Karnataka, India
2. Assam down town University, Dept. of Pharmacy, Sankar Madhab Path Panikhati, Guwahati-26, Assam, India.
3. Department of Pharmaceutics, PES College of Pharmacy, Hanumanth nagar, Bangalore, Karnataka, India
4. Govt. Ayurvedic College, Department of RS & VK, Guwahati-14, Assam, India.
Article history: Received: 15 July 2013, revised: 29 July 2013, accepted: 12 August 2013, Available online: 3 October 2013
Article ID- Hygeia.J.D.Med/113/13.
Plan: To synthesize some novel 2-amino thiophenes with various substitutions at 2-amino position for anti-platelet aggregation activity.
Preface: Various substituted and condensed thiophenes are reported to possess a wide variety of biological and pharmacological activities such as antibacterial, antifungal, anti-inflammatory, anti-platelet aggregation activity, antipyretic, antitumor and so on. Thus a series of new thiophenes have synthesized with various substituents at 2-amino position and screened for anti-platelet aggregation activity.
Methodology: The starting material (JMS-2) was prepared by the application of versatile Gewald reaction. It was then derivatized to various Schiff bases JMS-2(a-m) by reacting with various substituted aromatic aldehydes. The synthesized new compounds were characterized by MP, TLC, IR, NMR and Mass spectra and were screened for their In-vitro anti-platelet aggregation activity by GVR Born method using Heparin as the standard.
Outcome: Compound JMS-2a, JMS-2b, JMS-2d and JMS-2i showed good % inhibition and were found to be more significant.
Keywords: 2-amino thiophene, Gewald reaction, anti-platelet aggregation.
Jagadish ER, Mohan S,Saravanan J, Satyendra D*, Swetha Sree P, Apurba T, Manoj K, Rama Kanta S. Synthesis and in-vitroAnti-platelet aggregation activity of some New substituted Thiophenes, Hygeia.J.D.Med 2013;5(2):87-96.Availablefrom http://www.hygeiajournal.com / ArticleID- Hygeia.J.D.Med/113/13.
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Researcher Id: C-3213-2012
Antiplatelet Activity of JMS-2a,JMS-2b, JMS-2d and JMS-2i by GVR Bron method,