Abstract

Formulation and Evaluation of Metaprolol tartarate Non-effervescent Gastric Floating tablets. .

Hygeia.J.D.Med.6 (1) 2014; 63-73.

Bharat W Tekade*,Vinod M Thakare, Umesh T Jadhao, Sandeep B Khatale

Department of Pharmaceutics, TVES’s Honorable Loksevak Madhukar Rao Chaudhari College of Pharmacy, Faizpur, India.

Article history: Received: 1 January 2014,  revised: 24 February 2014, accepted: 10 March 2014, Available online: 3 April 2014

Plan: The Objective of this study was to develop Gastric floating drug delivery system containing Metaprolol and having a bulk density lower than that of gastric fluid remaining buoyant on the stomach contents.

 Preface: Metaprolol tartarate is having short to moderate half life 3-7 hrs, low bioavailability hence it is worth able to formulate Metaprolol in floating drug delivery. The GRDDS can improve the controlled delivery of the drugs which exhibit an absorption window by continuously releasing the drug for a prolonged period before it reaches its absorption site, thus ensuring its optimal bioavailability

Methodology: Percentage Drug content in all floating tablet formulations was found to be95.85% to 103.33% which was within Pharmacopoeial limit. In- vitro drug release profile from all formulations (F1-F10) showed sustained release of Metaprolol Tartarate over a period of 10 hours.

Outcome: Among all the formulation, F3 showed drug release up to 94.71% at the end of 10 hours.The mechanism of the drug release from F3 was anomalous transport, first order release kinetics. Stability studies on optimized batch showed no significant effect on physical properties,drug content, floating behavior and drug release.

Keywords: Gastro retentive floating tablets,Buoyancy, Metaprolol tartarate, HPMC, Kinetic studies.

For Correspondence: bharattekade @yahoo.co.in
Rid:C-7599-2014   

Citation: Bharat W Tekade*, Vinod M Thakare, UmeshTJadhao, Sandeep B Khatale. Formulation and Evaluation ofMetaprolol tartarate Non-effervescent Gastric Floating tablets. . Hygeia.J.D.Med 2014; 6(1):63-73. Available from http://www.hygeiajournal.com /Article ID- Hygeia.J.D.Med/123/14.DOI: 10.15254/H.J.D.Med.6.2014.123

                       IR spectrum of Metaprolol Tartarate                                                  IR spectrum of HPMC.