Hygeia journal for drugs and medicines


Formulation and Evaluation of Cream Containing Antifungal Agents, Antibacterial Agents and Corticosteroids

Hygeia.J.D.Med.6 (2) 2014;5-16.

A. Premkumar, T. Muthukumaran1,V. Ganesan2 , Shanmugam R3, Priyanka D.L4

1. Department of Biotechnology, Periyar Maniammai University,Thanjavur, Tamilnadu, India
2. Department of Pharmaceutics, Erode College of Pharmacy, Erode,Tamilnadu, India.
3. Department of Pharmaceutical Analysis, Sree Vidyanikethan College ofPharmacy, Tirupathy, Andhra Pradesh, India.
4. Department of Pharmacognosy, CES College of Pharmacy, (Affiliated to JNTU, Anantapur) Kurnool,Andhra Pradesh, India.


Plan: The main aim of our research was to develop a novel cream formulation consisting of combination of Miconazole nitrate, Mupirocin and Hydrocortisone for the treatment of secondary skin infections.

Prologue: Topical route is most suitable route for skin infections. The development of topical drug delivery systems designed to have systemic effects appears to be beneficial for a number of drugs on account of the several advantages over conventional routes of drug administration.

Methodology: A novel cream formulation consisting of combination of Miconazole nitrate, Mupirocin and Hydrocortisone was prepared. The formulation was subjected to in-vitro diffusion studies. Microbiological studies and in-vivo skin irritation studies were performed to find out the safety of materials used in the formulation. 

Outcome: The developed cream consisting of combination of Miconazole nitrate, Mupirocin, and Hydrocortisone was found to be safe and effective for the treatment of skin infections.

Keywords: Miconazole nitrate, Mupirocin, Hydrocortisone, Antifungal, antibacterial, Skin irritation studies. 

Received: 10 June 2014,  Revised: 2 July 2014, Accepted: 18 July 2014, Available online: 10 October 2014

Premkumar, T. Muthukumaran, V.Ganesan , Shanmugam R, Priyanka D.L. Formulation andEvaluation of Cream containing Antifungal agents, Antibacterial agents andCorticosteroids. Hygeia.J.D.Med 2014; 6(2):5-16.Available fromhttp://www.hygeiajournal.com / Article ID-Hygeia.J.D.Med/131/14.doi:10.15254/H.J.D.Med.6.2014.131.


A.Premkumar, Department of Biotechnology, PeriyarManiammai University, Thanjavur, Tamilnadu, India


Email: prem.srmu@gmail.com


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