Bioavailability Enhancement of Ziprasidone: Optimization of Carriers and Methods Employed
Hygeia.J.D.Med.6 (2) 2014; 57-70.
Murthy S N Varanasi 1, John S2, Srikar G1, Radha Madhavi B1
1. Department Of Pharmaceutics, University College Of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur
2. Department Of Pharmaceutics, Nirmala College of Pharmacy, Atmakur, Guntur
Plan: The main objective of the present research work was to enhance the dissolution rate of Ziprasidone by preparing the solid dispersions using different carriers like PVP, PEG 4000, SSG and β-Cyclodextrin.
Preface: Ziprasidone is a class-II drug according to Biopharmaceutical Classification System. It is practically insoluble in water and it has dissolution limited bioavailability. So, the present research work it is aimed to improve the dissolution rate through solid dispersion technique which further enhances the bioavailability.
Methodology: The solid dispersions were prepared at three ratios (1:1, 1:2 & 1:3) of each carrier by three different techniques viz. Physical mixtures, Kneading method and Solvent evaporation method. The characterizations of prepared solid dispersions were done by Differential Scanning Calorimetry (DSC) and they were also characterized for their drug content and in-vitro dissolution studies
Outcome: From DSC studies it was confirmed that the drug was dispersed in the carrier at molecular level in the obtained co-evaporates. From the results of dissolution studies, it was confirmed that the solid dispersions could enhance the bioavailability of Ziprasidone.
Key Words: Ziprasidone (ZPR), Solid dispersions, Co-evaporates, Bioavailability
Received: 12 August 2014, Revised: 10 September 2014, Accepted: 15 September 2014, Available online: 10 October 2014
Murthy S N Varanasi, John S, Srikar G, Radha Madhavi B. Hygeia.J.D.Med 2014; 6(2):57-77. Available from http://www.hygeiajournal.com / Article ID-Hygeia.J.D.Med/136/14. doi:10.15254/H.J.D.Med.6.2014.136.
Murthy S N Varanasi, Department of Pharmaceutics, University College of Pharmaceutical sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur