Synthesis, Characterization and Antimicrobial screening of some Novel Benzimidazoles
Hygeia.J.D.Med.7 (1) April 2015; 28-37
Bandita Sarma1, Shamanna Mohan1, JanardhanSaravanan1, Satyendra Deka2*, Pallab Kalita2, Nayan Talukdar3, Bhargav Nimavat1
1. Department of Pharmaceutical Chemistry, P.E.S. College of Pharmacy, Bangalore-50, Karnataka, India.
2. Assam down Town University, Dept. of Pharmacy, Panikhati, Guwahati-26, Assam, India
3. Assam down t own University, Dept. of Biotechnology, Panikhati, Guwahati-26, Assam, India.
Plan: Present work aims to synthesize a series of new benimidazoles (SBS-a-m) with various substitutions at 2-o-amino phenyl position and to evaluate their in-vitro antibacterial and anti-fungal activity.
Prologue: Benzimidazole containing organic compounds forms a significant group of drugs which exhibit an array of biological activities ranging from antibacterial, antifungal, anti-inflammatory, analgesic, anthelmintic activities and so on.
Methodology: The starting material SBS was synthesized by microwave irradiation of o-phenylenediamine and anthranilic acid mixture in presence of polyphosphoric acid. SBS was further derivatized to Schiff bases (SBS-a-m) by reacting with various substituted aromatic aldehydes. The in-vitro antibacterial and anti-fungal activity was carried out by the agar diffusion method using Ampicillin and Miconazole nitrate respectively as standards at a concentration of 50µg/0.1ml.
Outcome: SBS-k was found to be most active on all the bacteria used and SBS-e showed good activity against both Gram-positive bacteria and moderate activity against both Gram-negative bacteria. No compound showed significant antifungal activity.
Key words: Benzimidazole, antibacterial activity, antifungal activity.
Bandita Sarma, Shamanna Mohan, Janardhanan Saravanan, Satyendra Deka, Pallab Kalita, Nayan Talukdar, Bhargav Nimavat . Syntheses, characterization and antimicrobial screening of some novel benzimidazoles. Hygeia.J.D.Med.7 (1) April 2015; 28-37. Available from http://www.hygeiajournal.com