Hygeia journal for drugs and medicines


Optimized tri-layered pulsatile tablet of salbutamol for chronodelivery in asthma.

Hygeia.J.D.Med. 2017; 9 (1):9-21

A J. Chacko* and  Jyoti Harindran
Dept. of Pharmaceutical Sciences, RIMSR, MG University, Rubber Board PO. Kottayam. 686009

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Plan: The study was aimed to develop a tri-layered pulsatile tablet of salbutamol sulphate for Chronotherapeutic delivery in bronchial asthma. The incidence of asthma is greatest in the early morning hours referred as “morning dip”.
Preface: A formulation which could deliver the drug in the right concentration just prior to the attack could effectively control the condition and staining drug release thereafter will further enable the dosage as once a day unit.
MethodologyThis formulation consists of three layers with the first layer for sustain release and the second for the burst release after a predetermined lag time and the third layer determines the lag time. A novel two-stage coating was employed to achieve the burst followed by sustained release.The bottom and the sides of the tablets were coated with an insoluble polymer, ethyl cellulose which acted as a cage for the dosage form all sides except the top. The caged unit was finally dip coated with pH sensitive polymer eudragitL.
Outcome: The formulation was optimised by Box-Behnken design and the composition suggested by the design expert successfully achieved the lag time of 5 hrs and cumulative drug release of 32% and 95% respectively at 6th and 24thhours

Chronotherapeutics, pulsatile, salbutamol sulphate, Trilayered tablet, Box-Behnken design, optimisation.



A. J. Chacko M.Pharm.

Dept. of Pharmaceutical Sciences, RIMSR, MG University, Rubber Board PO. Kottayam. 686009
email: ajchacko01 yahoo .co.in
    Mob: 0091 9447473432

Article History: Received: 11 January 2017,   Revised: 26 February 2017 Accepted: 11 March 2017, Available online: 5 July 2017

Article citation

A. J. Chacko*, Jyoti Harindran. Optimised tri-layered pulsatile tablet of salbutamol for Chrono delivery in asthma. Hygeia.J.D.Med2017; 9(1):9-21. Available from http://www.hygeiajournal.com , DOI:10.15254/H.J.D.Med.9.2017.161

Contour plot for the effect of guar gum concentration and HPMC concentration on cumulative percentage release at the 24th hour.


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