Hygeia journal for Drugs and Medicines

Abstract

GUT DYSBIOSIS AND NEUROLOGICAL DISORDERS: IS THE GUT THE MISSING LINK?


Formany years, neurological diseases were largely viewed as disorders originatingwithin the brain. Recently, researchers have found that the trillions ofbacteria that live in the gut seem to play a significant function in preservingbrain health. As a result, there has been a lot of interest in themicrobiota–gut–brain axis, particularly in figuring out how gut dysbiosis canbe connected to neurological and neuropsychiatric conditions. Gut dysbiosisrefers to an imbalance or alteration in the composition and function of theintestinal microbiota. It can result from several factors, including diet,ageing, medications, infections, lifestyle, and underlying disease. What isbecoming increasingly clear from recent research is that these microbialchanges may have effects well beyond the intestine. The gut microbiota producesa range of metabolites, including short-chain fatty acids, bile acidderivatives, and tryptophan metabolites, which can influence immune responses,intestinal barrier function, and communication with the nervous system.





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