Effect of Compression Pressure on the Activity of Lipase
Hygeia J. D. Med. Vol.1 (1) 2009, 11-13
(ISSN 0975 6221)
Type of Article
Prasanth S1*, Tholath Emilia Abraham2
1 Crescent College of Pharmaceutical Sciences, Payangadi, Kannur, Kerala
2 Chemical Science & Technology Division, National Institute of Interdisciplinary Science & Technology (NIIST) CSIR, Thiruvananthapuram, Kerala
Enzymes have been used extensively in therapy during the last century. Tablets are a suitable dosage form for application of these materials because the enzymes are formulated in the dry state and no decomposition in solution can occur. However, one major factor influencing the stability of enzymes is tablet compaction pressure. Overcoming this problem will be a major challenge in the future. It was the scope of this work to characterize the behavior of the lipase powder and immobilized lipase under pressure to gain information about the behavior of powder during the compression process and on the other hand to get more knowledge about the behavior of enzyme powder in pharmaceutical formulations. The free enzyme could not survive the smallest pressure used, where as the CLEA could withstand the compression.
Keywords: Lipase, Burkholderia cepacia, Cross Linked Enzyme Aggregate (CLEA), Glutaraldehyde, Kappa carrageenan
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