Hygeia journal for drugs and medicines


Proton Pump Inhibitors
Hygeia J. D. Med. Vol.1 (1) 2009, 28-32
  (ISSN 0975 6221)

Type of Article 
Short Review

Swathi N1,  Durai Ananda Kumar T1*,  Yuvaraj S, Subrahmanyam C.V.S.1

1. Gokaraju Rangaraju College of Pharmacy, Hyderabad – 90, AP
2. Crescent College of Pharmaceutical Sciences, Madayipara, Payangadi, Kannur, Kerala


Acid-related disorders, including gastro esophageal reflux disease (GERD), duodenal ulcers, and gastric ulcers, are managed by H2 receptor antagonists and proton pump inhibitors (PPIs). PPIs represent first choice for treating acid-peptic ulcers inhibits the gastric- H+ / K+ -ATPase through covalent binding to cysteine residues of the proton pump. Achlorhydria and acute renal failure are the most common drawbacks. A reversible acid pump antagonist (APAs), currently in clinical trial removes these problems. The APAs are the conceivable future drugs for the treatment of acid-peptic disorders.

Keywords: Proton Pump Inhibitors, Acid pump antagonist, Gastro esophageal reflux disease

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