Synthesis, Analysis and Antibacterial Evaluation of Pyrazole Derivative
Hygeia J. D. Med. Vol.1 (1) 2009, 36-37
(ISSN 0975 6221)
Type of Article
Yuvaraj . S*, Sunith . D.K , Ahmed Riyaz T.K , Soumya E.N , Biji . P.K , Prajitha. P.P
Crescent College of Pharmaceutical Sciences, Madayipara, Payangadi, Kannur, Kerala
In the present study we had synthesised some pyrazole derivatives for finding potential antibacterial agents. Ethyl acetoacetate was reacted with benzene diazonium compound and the resulting compound was condensed with phenylhydrazine in presence of acetic acid to afford pyrazole compound. The synthesized compound was analyzed by physical and chromatography data. The presence of specific functional group in the product was confirmed by the IR spectroscopy and further structure determination by NMR and Mass spectroscopy is in progress. The in vitro antibacterial efficacy of synthesized compound was tested against Gram positive and Gram negative microorganisms by Cup and Plate method. The pyrazole derivative showed promising activity against Gram positive bacteria Staphylococcus aureus.
Key words: Pyrazole, Cup and plate method, Antibacterial.
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