Effect of microwave drying in improving granule characteristics in tablets
Hygeia.J.D.Med.Vol.2 (2), 2010, 8-13
Type of article: research article
Author: Deepthi Shyju.
Pushpagiri College of Pharmacy , Medicity campus , Perumthuruthy (P.O) , Tiruvalla , Kerala , India - 689107 .
Received: 20 June 2009,
Revised: 17 January 2010,
Accepted: 15 April 2010,
Available online: 20Sep.2010
In this study, Paracetamol was used as the model drug and the granules were prepared by microwave technique and fluid bed drying technique. The granules prepared by microwave technique and fluid bed drying technique were evaluated for parameters such as amount of fines, drying time, bulk density,compressibility,angle of repose etc.The data indicated that the granules retained their structure in comparison with the conventional drying process. The prepared granules were compressed into tablets and evaluated for hardness, friability, disintegration, and dissolution etc.
Keywords: Paracetamol tablets, Microwave drying, fluid bed drying
2. Formulation of granules
3. Evaluation of granules
3.1. Percentage of fines
3.2. Moisture content determinations
3.3. Bulk density
3.5. Flow properties
4. Preparation of tablets
5. Results and discussion
(In Vitro dissolution profiles of two batches of tablets prepared by microwave and F.B.D methods)
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