Visible Spectrophotometric method for the estimation of Cefepime
Hygeia.J.D.Med.Vol.2 (2), 2010, 32-37.
Type of article: research article
Authors: Minu Sujith1, Sujith Abraham1*and Madhu.C.Divakar2
1. Nirmala College of Pharmacy, Muvattupuzha, Ernakulam , Kerala , India - 686661
2. Crescent College of Pharmaceutical Sciences ,Payangadi.P.O , Kannur, Kerala , India 670358 .
Received: 10 January2010,,
Accepted:18 june2010 ,
Available online 31 July 2010.
A simple, accurate and reproducible visible spectrophotometric method was developed for the estimation of cefepime in pure and vial formulation. Cefepime with 1-Chloro-2,4-dinitrobenzene in presence of dimethyl sulfoxide at 45oC have formed a yellow colored complex having maximum absorbance at 420nm.The calibration graph was linear in the range 20µg/ml to50µg/ml.
: Visible spectrophotometry, Cefepime, 1-Chloro-2, 4-dinitrobenzene, Dinitrobenzene
2.1. Instruments used
2.2. Chemicals and reagents
2.3. Preparation of standard drug solution
2.4. Analysis of pharmaceutical formulation
2.5. Recovery studies
3. Results and discussion
Beer's -Lambert's plot of cefepime at 420 nm
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