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Synthesis and Antimicrobial screening of some Novel Substituted Thiophenes

Hygeia.J.D.Med.4 (1), April 2012-October 2012, 112-118

Authors: Mohammad Asif Iqbal C 1, Satyendra D 2*,Apurba T 2, Patel M1, Monika K1,GirishK 1, Mohan S 1, Saravanan J 1

Affiliations:

1. Department of Pharmaceutical Chemistry, PES College of Pharmacy, Hanumanthnagar, Bangalore, Karnataka, India

2. Assam down town University, Dept. of Pharmacy, Panikhati, Guwahati-26, Assam, India.

Article history:

Received: 10 February, 2012,

Revised: 23 February, 2012,

Accepted: 10March, 2011,

Available online: 5 April 2012

Abstract

Plan: To synthesize some novel 2-amino thiophenes with various substitutions at 2-amino position for antibacterial and antifungal activity.

Prologue: Thiophenes containing organic compounds forms a significant group of drugs which exhibit an array of biological activities like anti-inflammatory, antibacterial, antifungal, anti-neoplastic, antiarthritic etc. Thus a series of new thiophenes have synthesized with various substituents at 2-amino position and screened for antimicrobial activity.

Methodology: The parent compound 2-amino-3-(N-furfuryl amido)-4, 5-dimethyl thiophene was synthesized by condensing butan-2-one with furfurylcyano acetamide in presence of sulphur and diethylamine. It was then derivatized to various Schiff bases by reacting with various substituted aromatic aldehydes. The synthesized new compounds were characterized by MP, TLC, IR, NMR and Mass spectra and were screened for their antibacterial and antifungal activity by using Ampicillin and Miconazole nitrate as standard respectively.

Outcome: The compounds MAI-2e, MAI-2k, & MAI-2l showed potent antibacterial and MAI-2a, MAI-2c, MAI-2e, & MAI-2f showed potent antifungal activity.

Keywords: 2-amino thiophenes, Schiff bases, Antimicrobial activity, S.aureus, B.subtilis, E.coli, K. pneumoniae

Article outline:

1. Intorduction

2. Experimental

3. Results and discussion

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http://www.researcherid.com/rid/C-3213-2012