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Simple Spectrophotometric determination of Tegaserod Maleate in Pharmaceutical dosage forms

Hygeia.J.D.Med. 2013; 5(1):59-62.

Helen William*, Bijumol C, Jose Kurien and Thomas Kurian

College of Pharmaceutical Sciences, Govt. Medical College, Kottayam, Kerala

Article history: Received: 22 December 2012,   revised: 12 January 2013, accepted: 2 February 2013, Available online: 3 April 2013

Abstract

Plan: An analytical method for the estimation of Tegaserod Maleate in bulk drugs and pharmaceutical dosage forms is described.

Prologue: Tegaserod Maleate is the first selective serotonin 5-HT4 receptor partial agonist to improve symptoms of constipation-predominant Irritable Bowel syndrome. The present study aims at the development of simple Spectrophotometric method for the estimation of Tegaserod in dosage forms.

Methodology: The developed method is based on the formation of a purple coloured complex due to the reaction of Tegaserod Maleate with p-Dimethylaminobenzaldehyde reagent, which gave a maximum absorbance at 515nm. Beer’s law is obeyed over the concentration range of 5-50µg/ml. All the variables were studied to optimize the reaction conditions.

Outcome: The proposed method is simple, fast, accurate and economical and can be used for the routine analysis of Tegaserod in dosage forms.

Keywords: Tegaserod Maleate, p-Dimethylaminobenzaldehyde, Spectrophotometric method

 

 

Helen William, Bijumol C, Jose Kurien and Thomas Kurian. Simple Spectrophotometric determination of Tegaserod Maleate in Pharmaceutical dosage forms. Hygeia.J.D.Med. 2013; 5(1):59-62.Available from http://www.hygeiajournal.com /Article ID-Hygeia.J.D.Med/88/13.
 

For Correspondence: helenwilliam2012@ymail.com
Hygeia.J.D.Med. Vol.5 (1), April 2013
© 2013, Hygeia journal for drugs and medicines, 
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Researcher ID: J-8343-2012