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Drug Delivery using genetically modified Mesenchymal Stem Cells: A promising targeted-delivery method

Hygeia.J.D.Med. 2013; 5(1):90-104

Ammar Ebrahimi1*, Neda Lalvand2

1. Department of Medical Biotechnology, School of Advanced Medical Technology, Tehran University of Medical Sciences, Tehran, Iran

2. Department of Biology, School of Sciences, Shahid Chamran University, Ahvaz, Iran

Article history: Received: 25November 2012, revised: 20 December 2012, accepted: 1January 2013, Available online: 3 April 2013

Abstract

Plan: The review covers the unique role of Mesenchymal stem cells to improve, the poor solubility, premature metabolic inactivation, excretion and bioavailability of different classes of drugs which are insoluble or sparingly soluble in water.

Preface: Mesenchymal stem cells (MSCs) exhibit unique characteristics including their ability to differentiate and migrate to sites of tissue injury/inflammation, genetic modifiability, and expression of protein. Many of the most promising drug targets are intracellular and can only be accessed by drugs capable of traversing the cell membrane. Gene and drug delivery using genetically modified cells offers several unique advantages including ease of modifying, inducible or continuous drug production inside the body, more control on drug target and safety.

Outcome: In this review article, we examine the promising of using MSCs as a drug delivery vehicle for gene therapy, and summarize various challenges and concerns regarding these therapies.

Key words: Mesenchymal stem cell, Drug delivery, Gene delivery

Ammar Ebrahimi, Neda Lalvand. Drug Delivery using genetically modified Mesenchymal Stem Cells: A promising targeted-delivery method. Hygeia.J.D.Med. 2013; 5(1):90-104. Available at http://www.hygeiajournal.com / Article ID- Hygeia.J.D.Med/93/13