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Evaluation of Phoenix dactylifera fruits for Antiurolithiatic activity

Hygeia.J.D.Med. 2013; 5(1):135-140

Challa Srinivas Reddy*, Pradeep Vardhaman

Vaagdevi College of Pharmacy, Hanamkonda, Warangal, Andhra Pradesh., India.

 

Article history: Received: 5 January 2013,   revised: 20 January 2013, accepted: 15 February 2013, Available online: 3 April 2013

 

Abstract:

Plan: Phoenix dactylifera L. of Arecaceae (Palmae) family is consumed worldwide as an edible fruit. Reviews indicated the use of fruit as antioxidant, anticancer, antilipaemic and antidiabetic in many traditional treatments. In the present study the antiurolithiatic activity of P. dactylifera fruits are reported.

Materials and Methods: The n-Butanol and Aqueous extract preparations were made and administered as test compounds, Cystone as reference standard in five groups. Ethylene glycol induced hyperoxaluria is selected as a screening method for induction of kidney stones and the levels of creatinine, urea and uric acid are analysed.

Outcome: The n-butanol and aqueous extracts of P. dactylifera fruits in the doses of 200mg/kg reduced creatinine, urea, uric acid levels, significantly  in comparison with the control.  But both the extracts showed results less than the standard drug 'Cystone' and the n-butanol extract was more effective than aqueous extract to decrease urea and uric acid levels. Among these two extracts the n-butanol extract exhibited more antiurolithiatic activity.

Keywords: Phoenix dactylifera, Ethylene Glycol, Urea, Uric Acid, Antiurolithiatic Activity.

 

 

Challa Srinivas Reddy, Pradeep Vardhaman .Evaluation of Phoenix dactylifera fruits for Antiurolithiatic activity. Hygeia.J.D.Med. 2013; 5(1):135-140. Available at   http://www.hygeiajournal.com / Article ID- Hygeia.J.D.Med/98/13

For Correspondence ::challa_cnu@yahoo.com   ,
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Hygeia.J.D.Med. Vol.5 (1), April 2013
© 2013, Hygeia journal for drugs and medicines, 
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Researcher ID:  K-5130-2012A