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Anti-anxiety activity of Gloriosa superba Linn.

Hygeia.J.D.Med. 2013; 5(1):148-151

 

R  Sundaraganapathy1*, V Niraimathi2, Ananda Thangadurai1, D Kamalakannan1,  

B Narasimhan3 and Aakash Deep3

 

1. Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode-637 205, India.

2. College of Pharmacy, Madras Medical College, Chennai, India.

3. Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak – 124 001, India.

Article history: Received: 20 December 2012,   revised: 15 February 2013, accepted: 24 February 2013, Available online: 3 April 2013

Abstract

Plan: Anti-anxiety activity of Gloriosa superba Linn. 

Prologue: Gloriosa superba Linn. (Family: Liliaceae) is widely used as a medicinal plant. Gloriosa superba Linn. has several therapeutic applications including anti inflammatory, anthelmintic, abortifacient, oxytocic, analgesic antimicrobial and mutagenic activities. The petroleum ether and ethanol extracts of powdered aerial part of Gloriosa superba Linn. were studied   for anti-anxiety activity.

Methodology: Anti-anxiety activity of G. superba Linn  were studied by using Elevated Plus Maze (EPM) model in albino mice.

Outcome: Albino mice were treated orally with dose 300 mg/kg of the extracts and behavior was observed on the EPM. Diazepam (2mg/kg, P.O) was used as a positive control. The results indicated that alcoholic extract exhibited significant result as compared to the standard drug.

Keywords: Gloriosa superba Linn., Elevated plus Maze, anti-anxiety activity

 

R  Sundaraganapathy, V Niraimathi, Ananda Thangadurai, D Kamalakannan,  B Narasimhan and Aakash Deep. Anti-anxiety activity of Gloriosa superba Linn. Hygeia.J.D.Med. 2013; 5(1):148-151. Available at   http://www.hygeiajournal.com / Article ID-Hygeia.J.D.Med/100/13

 

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Hygeia.J.D.Med. Vol.5 (1), April 2013
© 2013, Hygeia journal for drugs and medicines, 
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Researcher ID: A-1138-2013