Full Text
A systematic review on the synthesis and biological activity of hydrazide derivatives.
Hygeia.J.D.Med. 2017; 9 (1):61-79
DOI: 10.15254/H.J.D.Med.9.2017.165
Google scholar
Mohd.ShahnawazKhan1*, Saba Parveen Siddiqui2 and Nazia Tarannum3.
1. Department of Chemistry JK Lakshmipat University, Jaipur Rajasthan, India 302026.
2. Department of Chemistry, Kendriya Vidyalaya No-1 Pratap Nagar, Udaipur Rajasthan, India 313100.
3. Department of Chemistry, Chaudhary Charan Singh University, Meerut Uttar Pradesh, India. 250004.
ABSTRACT
Plan: A systematic review on the synthesis and biological activity of hydrazides and their derivatives.
Preface: The chemistry of hydrazide and its derivatives has obtained a great interest in both organic chemistry and biological science with remarkable impact. The development of novel organic compounds with antimicrobial, antiviral, anti-inflammatory, anti-tubercular, antibacterial, antifungal activities has been of great interest and pharmaceutical importance. Hydrazides and hydrazones are possessing an NHNH2 and NHN=CH- groups respectively. The availability of proton in hydrazides constitutes them as an important class of compound for new drug discovery. Therefore, researchers have shown great interest in developing these compounds as target structures for evaluating new biological activities.
Outcome: This review emphasises on various methods of synthesis and several biological activities possessed by hydrazide and hydrazone derivatives, which may help the researchers for the design and development of novel hydrazides as a potential candidate in pharmaceutical science.
Keywords: Synthesis, Biological activities, Hydrazides, Hydrazone
Correspondence
Mohd. Shahnawaz khan M.Sc., PhD, MIAEAC, MISCB, MACS, FICC, FICS
Department of Chemistry, JK Lakshmipat University, Jaipur Rajasthan, India 302026.
Email: shaanorganic79@gmail.com
Phone: 91-141-2259546, Mob: 08561031705
Researcher ID: D-5175-2017
Article History: Received: 30 December 2016, Revised: 30 January 2017Accepted: 15 March 2017, Available online: 15 July 2017
Article citation
Mohd.Shahnawaz Khan*, Saba Parveen Siddiqui and Nazia Tarannum. A systematic review on the synthesis and biological activity of hydrazide derivatives. Hygeia.J.D.Med 2017; 9(1):61-79. Available from http://www.hygeiajournal.com , DOI: 10.15254/H.J.D.Med.9.2017.165
Hydrazides and Hydrazones with anti-inflammatory and antimicrobial activity.